Magnetic Nanomarkers for Disease Diagnosis and Treatment:

Trends and Opportunities for Precision Medicine

Authors

DOI:

https://doi.org/10.55747/bjedis.v4i2.69017

Keywords:

magnetic iron nanoparticle, quantum dot, theranostics, cell tracking, magnetic nanomarker, drug delivery, data analysis

Abstract

The field of diagnostics and therapies has been focuses significantly on the development of nanoparticulate systems with multifunctionalities. The aim of this article was to understand emerging technological and market trends in the sector, using the technological roadmap methodology, with a focus on magnetic nanomarkers functionalized with quantum dots for cell tracking. Thus, universities are the dominant players in terms of publications and inventions, revealing an initial phase of technological development, corroborated by the evident collaboration between companies and universities. Among the nanomarkers, carbon quantum dots, ZnS and CdSe are prominent, often associated with iron oxide nanoparticles and preferably used in Magnetic Resonance Imaging (MRI) and Fluorescence methods, mainly drug delivery. In short, the potential of proven nanoparticles in cell tracking points to advances in the diagnosis and non-invasive treatment of various diseases, with particular emphasis on cancer, whether in general or specific terms, such as breast cancer and hepatocarcinoma, and on HeLa cells, which are emerging as the main focus for the application of these markers.

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Author Biographies

Aline Tavares, UFRJ

Bioprocess Engineer (UFRJ), Master in Chemical and Biochemical Process Technology (UFRJ) and PhD candidate in Chemical and Biochemical Process Engineering (UFRJ) in the area of Management and Technological Innovation. Professional with experience in management and technological innovation, executing and technically coordinating Strategic Planning, Technological Prospecting, and Technological Roadmap projects for various industry segments, covering a range of topics, including the circular economy, renewable energy, biofuels, the bioeconomy, occupational health and safety, among others. I am the coauthor of three books: “Circular Economy: A New Mindset on sustainable development”, published by Editora Brasport, the book “Catalyzing the Circular Economy: concepts, business models and their application in sectors of the economy”, published by Editora UFRJ, and "Technology Roadmap: Cases and Opportunities, published by Editora Appris. 

Heshiley Cristhiane Correia, Magtech Soluções em Nanopartículas Magnéticas Ltda

Master's degree in Chemical and Biochemical Process Engineering from UFRJ and a bachelor's degree in Materials Engineering from UFRRJ. Experience in R&D projects with the following themes: reuse of waste, physical and chemical characterizations, processing and characterization of cement slabs, synthesis of silica nanoparticles and synthesis conditions for homogeneous and scalable production of silica nanoparticles and synthesis of quantum dots for electronic and photovoltaic applications. Participations in start-up acceleration programs and currently works as an innovation project manager at Magtech Brasil.

Lizandra de Macedo Nogueira, Magtech Soluções em Nanopartículas Magnéticas Ltda

Bachelor's and Master's degree in Engineering, specializing in finance. Extensive experience in business consultancy for small businesses and startups. Knowledge of process mapping, management and auditing techniques, Lean Six Sigma methodology, financial analysis and management and the innovation environment.

Marcel Guimarães Martins, Magtech Soluções em Nanopartículas Magnéticas Ltda

Chemical Engineer, graduated from Universidade Federal Fluminense (UFF), Master's and PhD from Universidade Federal do Rio de Janeiro (PEQ/COPPE/UFRJ). Main line of research is the development of multifunctional nanoparticles for biotechnological applications. CEO&CTO of Magtech Brasil, a university-based technology company that develops solutions for the biotechnology market with a focus on health. Director of RD&I-Market Relations at ANBIOTEC Brasil (National Association of Biotechnology and Life Sciences Companies) for the 2021-2022 biennium. Also works as an Innovation Project Specialist at FIOCRUZ and as a mentor/consultant for structuring technology-based companies.

Suzana Borschiver, Federal University of Rio de Janeiro

Chemical Engineer with a Degree in Chemistry from the State University of Rio de Janeiro (UERJ - Universidade Estadual do Rio de Janeiro). Master and PhD in Chemical Engineering from the Federal University of Rio de Janeiro (UFRJ - Universidade Federal do Rio de Janeiro). Full Professor at the School of Chemistry/UFRJ, in the area of Management and Technological Innovation. Coordinator of the Centre for Industrial and Technological Studies (NEITEC), of the Extension Project “Catalysing Circular Economy” at the School of Chemistry/UFRJ and Vice Coordinator of PROFNIT- Professional Master in Intellectual Property and Technology Transfer - Focal Point UFRJ. Member of the Brazilian National Council for Energy Policy (CNPE) - Specialist in Technological Roadmap, Circular Economy, Energy Transition, Technological Prospecting and Innovation, Industrial Studies and Strategic Planning.

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