Chitosan-based films for wound healing applications: A meta- analysis to access the impact on wound closure rate

Authors

  • Thaís Nogueira Barradas Departamento de Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal de Juiz de Fora, Juiz de Fora, Brasil
  • Fernando Gomes de Souza Junior Instituto de Macromoléculas: Professora Eloisa Mano, Centro de Tecnologia-Cidade Universitária, Universidade Federal de Rio de Janeiro, Rio de Janeiro, Brasil https://orcid.org/0000-0002-8332-4953

DOI:

https://doi.org/10.55747/bjedis.v2i1.52473

Keywords:

Chitosan films, wound healing, wound closure rate, Data mining, Statistical analysis, Bibliometrics

Abstract

Wound healing novel materials have been emerging as a hot topic, as wounds are reaching epidemic proportions, with both economic and psychosocial consequences. Chitosan-based films increase the rate of re-epithelialization and wound closure rate which, due to their antimicrobial properties, should contribute to wound closure. With the constant raise of scientific publications regarding this subject, we aimed to establish a direct relation of chitosan films on wound closure rate based on recent data. The available literature was gathered from Scopus database, followed by a bibliometric analysis. Results were sorted based on wound closure metrics and statistical information. The data extracted from the selected articles were analyzed and compared regarding the wound closure rate measured in animal models. The results showed good homogeneity of positive results among the studies selected. On the other hand, due to unstandardized parameters in chitosan films formulations among the articles studied here, no correlation with chitosan concentration in wound dressing films with the wound
closure effect could be observed. However, further investigations of such correlation with clinical tests are still needed. In this context, this work demonstrated consistency in the positive impact of chitosan films on wound healing, demonstrating that
chitosan films have the potential for biomedical use and their research is justified. The results of this work might help to understand the relationship between the actual contribution of chitosan and in vivo wound healing evaluation, and provide a
reference to new approaches for the treatment chronic wounds.

Author Biography

Fernando Gomes de Souza Junior, Instituto de Macromoléculas: Professora Eloisa Mano, Centro de Tecnologia-Cidade Universitária, Universidade Federal de Rio de Janeiro, Rio de Janeiro, Brasil

Associate (III) Prof. Fernando Gomes: Expertise focused in the use of renewable resources and nanocomposites in sensors, drug delivery and environmental recovery. Coordination of more than ten research projects with financial support from Brazilian government sponsoring agencies. Published 160 scientific articles plus 13 accepted for publication during 2021. Published 8 books. Among them,3 chemistry books in Portuguese and 3 books about Biopolymers in English. He has published more than two hundred papers in Conferences and Scientific meetings. Co-convener of the Sixth International Conference on Natural Polymers, Biopolymers and biomaterials: Applications from macro to nanoscale (http://www.biopolymers.macromol.in/), Chairman of the Fifth International Conference on Natural Polymers, Biopolymers and biomaterials: Applications from macro to nanoscale (https://www.icnp2017rio.com/) and Chaiman of the 1st Brazilian Conference on Design of Experiments and Data Analysis (https://sites.google.com/pent.coppe.ufrj.br/conbrapa2020). Supervisor of 128 undergraduate students; 29 M.Sc. students, 14 Ph.D. students and 6 Post Doc. Nowadays I am the supervisor of 11 undergraduate students; 7 M.Sc. students, 10 Ph.D. students and 3 Post Doc. Associate Editor of the MedCrave Online Journal (MOJ) Polymer Science (ISSN: 2574-9773) since 2017. Editor of the Academic Journal of Polymer Science (ISSN: 2641-8282), since 2018. Member of the Editorial Board of Composite Interfaces (ISSN: 0927-6440), since 2021. Member of the editorial board of Current Applied Polymer Science (ISSN 2452-2716) since 2016 and Editor-in-Chief of Current Applied Polymer Science (ISSN 2452-2716) since 2020. Professor Gomes has founded the Brazilian Journal of Experimental Design, Data Analysis and Inferential Statistics in 2021, acting as its 1st Editor-in-Chief. Awardedtwice as Young Scientist of Rio de Janeiro State (FAPERJ 2011 and 2014), Chair Professorship on Nanoscience and Nanotechnology - Mahatma Gandhi University – India (2018), member of Post Graduate Program in Science and Technology of Polymers of the Macromolecules Institute / Federal University of Rio de Janeiro (UFRJ) since 2008, member of Post Graduate Program in Civil Engineering (COPPE/UFRJ) between 2015-2019 and member of Post Graduate Program in Nanotechnology (COPPE/UFRJ) since 2019.

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Published

2022-05-18

Issue

Vol. 2 No. 1 (2022)

Section

Articles

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AUTHORS DECLARATIONS AND COPYRIGHT TRANSFER LICENSE

We at this moment declare that the present paper is our original work and has not been previously considered, either in whole or in part, for publication elsewhere. Besides, we warrant the authors will not submit this paper for publication in any other journal. We also guarantee that this article is free of plagiarism and that any accusation of plagiarism will be the authors' sole responsibility. The undersigned transfer all copyrights to the present paper (including without limitation the right to publish the work in any and all forms) to BJEDIS, understanding that neglecting this agreement will submit the violator to undertake the legal actions provided in the Law on Copyright and Neighboring Rights (No. 9610 of February 19, 1998). Also, we, the authors, declare no conflict of interest. Finally, all funders were cited in the acknowledgments section.